I was having quite a bit of joint pain...especially in my knees. I had been taking 1500mg of Glucosamine with 1500mg of MSM for quite awhile, but hadn't noticed any difference. I figured taking some time off from exercising would help, but even after a month there wasn't much improvement. I read about USP Labs Super Cissus on a message board and folks were singing its praises so I figured it would be worth a try. After taking it for 2-3 days I noticed some improvement, but not as much as I had hoped for. I then remembered reading on some of the reviews how they started with more than the recommended dose and then worked there way down over a few days...so I did this. I took 6 capsules the first day, then 5, then 4 on the third day...which is where I stayed for a few days. I immediately noticed a big difference! I've also started using knee compression sleeves when I exercise to support my knees. I'd say my knees feel 95% better. Although I had read good things about this supplement I wasn't expecting much...but was VERY pleasantly surprised. I take 2-3 capsules a day now for a maintenance dose. Sometimes I even forget to take them, but my knees still feel okay. This will be a regular purchase from here on out!